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  • Anti-hnRNP U Monoclonal Antibody
產(chǎn)品名稱(chēng):

Anti-hnRNP U Monoclonal Antibody

產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
廠商性質(zhì): 生產(chǎn)廠家 產(chǎn)品時(shí)間: 2024-08-02
Anti-hnRNP U Monoclonal Antibody(Cat:K000059M) can be used for WB analysis of hnRNP U expression in the tissue and cell lysates(Dilution: WB1:1000 ; Reacts with:Human).

產(chǎn)品概述

品牌SOLARBIO/索萊寶貨號(hào)K000059M
規(guī)格50ul/100ul供貨周期現(xiàn)貨
主要用途WB

 Anti-hnRNP U Monoclonal Antibody

英文名稱(chēng)Mouse hnRNP U Monoclonal Antibody
別名hnRNP U
應(yīng)用WB
稀釋比例WB1:1000
交叉反應(yīng)Human
蛋白分子量110kDa
Gene ID3192
保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
儲(chǔ)存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 70% Glycerol.
純化方法Affinity purification
亞型IgG1
免疫原Purified recombinant human hnRNP U protein fragments expressed in E.coli.
性狀Lyophilized or Liquid
Swiss ProtQ00839
克隆號(hào)1B11-H2-B7
克隆類(lèi)型Monoclonal Antibody
來(lái)源Mouse
背景資料This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

 

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